Post-doctoral researcher – Functional Genomics in AML – Teilzeit, Vollzeit

Job Beschreibung

"Knowledge becomes health" – we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative departments. The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital. Post-doctoral researcher – Functional Genomics in AML (We are targeting applicants of all genders) Full time | limited unlimited to 2 years | Announcement number: 185-2025 The Department of Hematology and Oncology at the University Hospital Frankfurt provides a comprehensive range of diagnostic and therapeutic services for patients with solid tumors and malignancies of the hematopoietic system. Within this scientific environment, the research group led by Prof. Dr. med. Thomas Oellerich focuses on uncovering oncogenic signaling pathways, regulators of tumor viability, and mechanisms of resistance to therapies, with a primary emphasis on acute myeloid leukemia (AML) and aggressive lymphomas. For details, visit https://lymphoma-leukemia-research-frankfurt.de or refer to key publications, including: Phelan, Scheich et al., Cancer Cell (2024) Jayavelu, Wolf, Buettner et al., Cancer Cell (2022) Mohr et al., Cancer Cell (2017) Schneider, Oellerich et al., Nature Medicine (2017) Phelan et al., Nature (2018) The Oellerich Lab leverages cutting-edge proteogenomics and functional genomics to explore the molecular underpinnings of hematological cancers. The laboratory is part of the Frankfurt Cancer Institute (FCI) and the German Consortium for Translational Cancer Research (DKTK), supported by the research infrastructure of the University Hospital Frankfurt and the Georg-Speyer-Haus. Strategic collaborations with international institutions, including the NIH and the Dana-Farber Cancer Center, further enhance the lab's global impact. The lab is seeking a motivated postdoctoral researcher to join a project funded by the German Cancer Aid (Deutsche Krebshilfe). The role focuses on elucidating molecular mechanisms of oncogenesis and therapy resistance in AML. The candidate will develop multiplexed, high-throughput functional genomic screens to dissect the roles of oncogenic drivers and resistance pathways. The lab employs a wide array of experimental techniques, including: Single-cell CRISPR/Cas9 screening technologies Quantitative (phospho-)proteomics Next-generation sequencing (NGS) and single-cell RNA sequencing Fluorescence-activated cell sorting (FACS) and advanced flow cytometry High-resolution imaging technologies, such as proximity ligation assays (PLAs) and super-resolution microscopy Computational biology For an insight into the University Hospital Frankfurt, click here . Your role Independent establishing of multiplex, high-throughput genomic screens in AML Independently design and carry out follow-up scientific projects, plan, establish, and analyze in vitro as well as in vivo experiments Handling of primary patient material for example bone marrow MNCs, perform FACS analysis and quantification Write manuscripts and grants Presentation of scientific data at national and international conferences Train and instruct scientific employees (technical assistants, MD and PhD doctoral candidates) allocated to the project Who you are The applicant should hold a PhD degree in biology, biochemistry, molecular medicine or a related life science, ideally in cancer research Theoretical and practical expertise in molecular biology (e.g. cloning, PCR) and protein biochemical techniques-experimental as well as in cell culture (e.g. production of virus particles for genomic modifications) techniques Experience with the principles and application of functional genomic tools such as CRISPR/Cas9-based technologies Expertise with high-throughput genomic assays (e.g. bulk and/or single cell RNA-sequencing) is an advantage Experienced handling of analytical software (e.g. Office, FlowJo, Illustrator) is required, additional (bio)informatics skills (e.g. processing and analysis of sequencing data using software, R or Python) or a strong interest to acquire these skills is encouraged Track records of publications in peer-reviewed journals are expected A high level of motivation and interest in answering scientific questions in an interdisciplinary academic cancer research setting Flexibility and responsibility, as well as very good communication skills in German or English Motivation to learn, apply, and establish new techniques, ability to critically analyze and reflect data Due to legal regulations, valid proof of measles immunity / measles vaccination is required What we offer We offer you an interesting, versatile, and attractive working environment in a highly motivated, international team consisting of MDs and PhDs with background in basic science, cancer biology and translational leukemia / lymphoma research in a lab with modern state-of-the-art infrastructure ; access to comprehensive further training program with access to DKTK School of Oncology and Mildred-Scheel Network Collective agreement: In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes Mobility: Free public transport in all Hessen (Free State Ticket Hessen) Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces. A walk on the riverside of the Main offers relaxation during breaks Work-Life-Balance: Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact UKF-Familienservice), child care during holidays Health Promotion: Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and exercise. Professional development: Internal and external training for your professional development Any questions? Many answers can be found in our FAQs for new employees. If you have any further questions, please do not hesitate to contact us. Women are underrepresented in these positions at the University Hospital Frankfurt. Applications from women are therefore particularly welcome. Disabled applicants are preferred if they have the same personal and professional qualifications. Join our team Use the time until March 4, 2025 to apply. Please submit your online application including a possible starting date and your salary expectations. For further information regarding the position and project, please contact Dr. med. Sebastian Wolf (E-Mail: wolf@em.uni-frankfurt.de ) . Apply now Universitätsmedizin Frankfurt | Recruiting Team | Theodor-Stern-Kai 7 | 60590 Frankfurt am Main | Bitte reichen Sie Ihre Bewerbung ausschließlich über den Button „Online bewerben“ ein. Rückfragen können Sie gerne an bewerbung@unimedizin-ffm.de richten. Bitte beachten Sie, dass keine Unterlagen zurückgeschickt werden. | Folgen Sie uns auf Instagram ( @unimedizin-ffm ); XING , LinkedIn .